Carboxylic acid derivatives and pharmaceutical agent comprising the same as active ingredient
US7786161B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Oct 27, 2008 |
| Grant date | Aug 31, 2010 |
| Priority date | — |
| Expiry date | Feb 10, 2029 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D249/08
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A carboxylic acid derivative of formula (I):wherein R1 is —COOH, —COOR6, etc.; A is a single bond, alkylene, etc.; R2 is alkyl, alkoxy, etc.; B is a carbocyclic ring or a heterocyclic ring; Q is alkylnene-Cyc2, etc.; D is a linking chain; and R3 is alkyl, a carbocyclic ring or a heterocyclic ring, or a non-toxic salt thereof. The compound of formula (I) binds to PGE2 receptor, especially subtypes EP3 and/or EP4 and show the antagonizing activity, are useful for the prevention and/or treatment of diseases induced pain, itch, urticaria, allergy, urinary frequency, urinary disturbance, Alzheimer's disease, cancer, dysmenorrhea, endometriosis, etc.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.