Compounds and methods for nucleic acid mismatch detection
US7786298B2 · kind B2 · utility
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3References
19Claims
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Key dates
| Filing date | Jan 12, 2007 |
| Grant date | Aug 31, 2010 |
| Priority date | — |
| Expiry date | Oct 2, 2028 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q1/6827
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
In accordance with the present invention there are provided sterically demanding intercalators. These compounds are useful for detection of a base-pair mismatch, such as by measuring fluorescence of complexes formed by the compounds of the invention and nucleic acid duplexes. The compounds are also capable of catalyzing photolytic cleavage of nucleic acids.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.