Fiber optic device for sensing analytes and method of making same

US7787923B2 · kind B2 · utility

Assignee

• Becton, Dickinson and Company · US

Inventors

• Javier Alarcon · Durham, US
• Kristin Weidemaier · Raleigh, US
• Terry J. Amis · Cary, US
• John D. DeNuzzio · Chapel Hill, US
• Christopher C. Herdman · Chappaqua, US
• Ross Jacobson · Hillsborough, US
• J. Bruce Pitner · Durham, US
• Douglas B. Sherman · Durham, US
• Steven Keith · Chapel Hill, US

Key dates

• Filing date: Oct 19, 2004
• Grant date: Aug 31, 2010
• Expiry date: Mar 4, 2028

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2201/1211
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

A device for sensing analyte concentration, and in particular glucose concentration, in vivo or in vitro is disclosed. A sensing element is attached to the distal end of an optical conduit, and comprises at least one binding protein adapted to bind with at least one target analyte. The sensing element further comprises at least one reporter group that undergoes a luminescence change with changing analyte concentrations. Optionally, the optical conduit and sensing element may be housed within a cannulated bevel.