Receptor-avid exogenous optical contrast and therapeutic agents
US7790144B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Mar 15, 2004 |
| Grant date | Sep 7, 2010 |
| Priority date | — |
| Expiry date | Oct 2, 2026 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC09B23/086
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Cyanine dye bioconjugates useful for diagnostic imaging and therapy are disclosed. The conjugates include several cyanine dyes with a variety of bis- and tetrakis (carboxylic acid) homologes. The compounds are be conjugated to bioactive peptides, carbohydrates, hormones, drugs, or other bioactive agents. The small size of the compounds allows more favorable delivery to tumor cells as compared to larger molecular weight imaging agents. The various dyes are useful over the range of 350 to 1,300 nm, the exact range being dependent upon the particular dye. The use of a biocompatible organic solvent such as dimethylsulfoxide helps to maintain the fluorescence of the compounds. The inventive compounds are useful for diagnostic imaging and therapy, in endoscopic applications for the detection of tumors and other abnormalities, for localized therapy, for photoacoustic tumor imaging, detection and therapy, and for sonofluorescence tumor imaging, detection and therapy.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.