Methods for treating neurological deficits by intrastriatal administration of transforming growth factor alpha (TGF-α)
US7790669B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Aug 4, 1998 |
| Grant date | Sep 7, 2010 |
| Priority date | — |
| Expiry date | Aug 4, 2018 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention features methods and compositions for treating a patient who has a neurological deficit. The method can be carried out, for example, by contacting (in vivo or in culture) a neural progenitor cell of the patient's central nervous system (CNS) with a polypeptide that binds the epidermal growth factor (EGF) receptor and directing progeny of the proliferating progenitor cells to migrate en masse to a region of the CNS in which they will reside and function in a manner sufficient to reduce the neurological deficit. The method may include a further step in which the progeny of the neural precursor cells are contacted with a compound that stimulates differentiation.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.