Compounds comprising an oxazole or thiazole moiety, processes for making them, and their uses

US7790720B2 · kind B2 · utility

Assignee

• UCB PHARMA S.A. · BE

Inventors

• Sylvain Celanire · Geneva, CH
• Frederic Denonne · Brussels, BE

Key dates

• Filing date: Mar 28, 2006
• Grant date: Sep 7, 2010
• Expiry date: Mar 28, 2026

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to compounds comprising an oxazole or thiazole moiety of formula (I), processes for preparing them, pharmaceutical compositions comprising said compounds and their uses as H3-receptor ligands, Formula (I), wherein, A1 is CH, C(alkyl), C-halogen or N; R1 is hydrogen, halogen, C1-6 alkyl or alkoxy; R2 is, Formula (II′), A3 is O or S; R3 is hydrogen, halogen, C1-6 alkyl or alkoxy; R4 is hydrogen, halogen, C1-6 alkyl, alkoxy or —O-L; R5 is hydrogen or —O-L, wherein L is an aminoalkyl group and at least one of R4 and R5 should be —O-L.