Patent · US Active

Compounds capable of activating cholinergic receptors

US7790757B2 · kind B2 · utility

0Cited by

31References

12Claims

0Family size

Assignee

Targacept, Inc. · US

Inventors

William Scott Caldwell · Winston-Salem, US
Gary Maurice Dull · Lewisville, US
Balwinder Singh Bhatti · Winston-Salem, US
Srishailkumar B. Hadimani · Winston-Salem, US
Haeil Park · Nae-myeon, KR
Jared Miller Wagner · Stillwater, US
Peter A. Crooks · Lexington, US

Key dates

Filing date	Oct 31, 2007
Grant date	Sep 7, 2010
Priority date	—
Expiry date	Jan 4, 2028

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D213/73
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Compounds incorporating aryl substituted olefinic amine are provided. Representative compounds are (4E)-N-methyl-5-(3-pyridyl)-4-penten-2-amine, (4E)-N-methyl-5-(5-pyrimidinyl)-4-penten-2-amine, (4E)-N-methyl-5-(5-methoxy-3-pyridyl)-4-penten-2-amine, (4E)-N-methyl-5-(6-amino-5-methyl-3-pyridyl)-4-penten-2-amine, (2R)-(4E)-N-methyl-5-(3-pyridyl)-4-penten-2-amine, (2R)-(4E)-N-methyl-5-(5-isopropoxy-3-pyridyl)-4-penten-2-amine, (4E)-N-methyl-5-(5-bromo-3-pyridyl)-4-penten-2-amine, (4E)-N-methyl-5-(5-ethoxy-3-pyridyl)-4-penten-2-amine, (2S)-(4E)-N-methyl-5-(3-pyridyl)-4-penten-2-amine, (4E)-N-methyl-5-(5-isopropoxy-3-pyridyl)-4-penten-2-amine and (2S)-(4E)-N-methyl-5-(5-isopropoxy-3-pyridyl)-4-penten-2-amine.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.