Compounds and methods for thiol-containing compound efflux and cancer treatment
US7790762B2 · kind B2 · utility
6Cited by
19References
11Claims
0Family size
Assignee
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Key dates
| Filing date | Nov 15, 2005 |
| Grant date | Sep 7, 2010 |
| Priority date | — |
| Expiry date | Feb 26, 2026 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2121/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods for therapy of cystic fibrosis and other conditions such as cancer are provided. The methods comprise one or more agents capable of increasing thiol-containing compound transport via a transporter system (i.e. ABC transporters such as MDR-1 or MRP-2) in cells. Other embodiments include the use of agents to modulate transport of thiol-containing compounds within the cell. Therapeutic methods involve the administration of such agents to a patient afflicted with cystic fibrosis, cancer and/or another condition responsive to stimulation of thiol-containing compound transport.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.