Pleuromutilin derivatives containing a hydroxyamino- or acyloxyaminocycloalkyl group
US7790767B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jun 26, 2006 |
| Grant date | Sep 7, 2010 |
| Priority date | — |
| Expiry date | Nov 11, 2027 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C2603/99
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to Compounds of general formula (I), wherein R is hydrogen and R1 is hydroxy or acyloxy, or R is acyl and R1 is hydroxy or acyloxy, X is sulphur, oxygen or NR10, wherein R10 is hydrogen or (C1-4)alkyl; Y is sulphur or oxygen; R2 is hydrogen or one or more substituents, e.g. including substituents such as conventional in organic, e.g. (pleuro)mutilin, chemistry; R4 is hydrogen or (C1-4)alkyl; R5 is hydrogen or (C1-4)alkyl; R3 and R3′ are hydrogen, deuterium, or halogen; R6, R7 and R8 are hydrogen, halogen or deuterium; m is a number selected from 0 to 4, n is a number selected from 0 to 10, and p is a number selected from 0 to 10; with the proviso that n plus p are at least 1. These Compounds are usefül as pharmaceuticals, particularly as antimicrobials.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.