Synthesis of human secretory IgM and the treatment of clostridium difficile associated diseases herewith
US7794721B2 · kind B2 · utility
Inventor
Key dates
| Filing date | Sep 7, 2007 |
| Grant date | Sep 14, 2010 |
| Priority date | — |
| Expiry date | Sep 7, 2027 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2317/52
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A composition for treating a subject is provided. The composition includes a pentameric secretory IgM therapeutic. Formulating agents are mixed with the pentameric secretory IgM to yield a dosing form of a capsule, tablet, and a suppository. A process for manufacturing a medicament for the treatment of C. difficile associated disease in a human is also provided that the modification of pentameric IgM with secretory component to form a pentameric secretory IgM therapeutic. The pentameric secretory IgM therapeutic is then mixed with formulating agents to create a capsule, tablet, or suppository dosing form. The therapeutic is amenable to enrobement directly through microencapsulation or the dosing form is coated with an enteric coating. A method of C. difficile treatment with the therapeutic is also provided that is amenable to supplementation with concurrent or prior antibiotic administration.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.