Microarray and uses therefor
US7794946B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Feb 4, 1999 |
| Grant date | Sep 14, 2010 |
| Priority date | — |
| Expiry date | Feb 4, 2019 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB01J2219/00659
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The invention disclosed herein comprises methods of using microarrays to simplify analysis and characterization of genes and their function. In one aspect of the invention the methods are used to identify and characterize antibodies having binding affinity for a specific target antigen. The invention further comprises a method of determining gene expression at the protein level comprising contacting an array of characterized or uncharacterized antibodies on a solid surface with one or more proteins and identifying the antibodies to which said protein(s) binds. This method can be additionally used to compare the protein expression in two different populations of cells, such as normal cells and cancer cells or resting cells and stimulated cells. A further aspect of the invention comprises a method of determining gene expression at the protein level comprising contacting a microarray of nucleic acid samples derived from a variety of different sources with one or more nucleic acid probes then identifying the sample or samples to which the probe binds.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.