Conformationally constrained parathyroid hormones with alpha-helix stabilizers
US7795220B2 · kind B2 · utility
2Cited by
93References
29Claims
0Family size
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Key dates
| Filing date | Mar 19, 2003 |
| Grant date | Sep 14, 2010 |
| Priority date | — |
| Expiry date | Aug 14, 2025 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P43/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to conformationally constrained parathyroid hormone (PTH) analogs and derivatives of those analogs. The invention also provides methods of preparing and using the PTH analogs. Further, the invention encompasses compositions and methods for use in limiting undesired bone loss in a vertebrate at risk of such bone loss, in treating conditions that are characterized by undesired bone loss or by the need for bone growth, e.g. in treating fractures or cartilage disorders and for raising camp levels in cells where deemed necessary.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.