Benzomorpholine derivatives and methods of use

US7795254B2 · kind B2 · utility

Assignee

• AMGEN INC. · US

Inventors

• Jean-Christophe Harmange · Poissy, FR
• Matthew W. Martin · Arlington, US
• Yohannes TEFFERA · Topsfield, US
• Raju Subramanian · Thousand Oaks, US
• Ryan White · Thousand Oaks, US
• Roger Zanon · Minneapolis, US
• Jay Larrow · Wakefield, US
• Joseph F. Payack · Somerville, US
• Mina Dilmeghani Seran · Ankara, TR

Key dates

• Filing date: Oct 28, 2008
• Grant date: Sep 14, 2010
• Expiry date: Oct 28, 2028

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P35/00
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Selected benzomorpholine compounds, including 7-((6,7-bis(methyloxy)-4-quinolinyl)oxy)-N-(5 -methyl-3-isoxazolyl)-2,3-dihydro-4H-1,4-benzoxazine-4-carboxamide, are effective for prophylaxis and treatment of diseases, such as VEGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.