Substituted tetrahydro-2H-isoquinolin-1-one derivatives, and methods for the production and use thereof

US7795278B2 · kind B2 · utility

Assignee

• Sanofi-Aventis Deutschland GMBH · DE

Inventors

• Stefan Peukert · Frankfurt am Main, DE
• Stefan Guessregen · Frankfurt am Main, DE
• Armin Hofmeister · Frankfurt, DE
• Herman Schreuder · Frankfurt am Main, DE
• Uwe Schwahn · Frankfurt am Main, DE

Key dates

• Filing date: Dec 6, 2006
• Grant date: Sep 14, 2010
• Expiry date: Apr 16, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention relates to compounds according to the general formula (I), where the definitions of the substituents R1, R2, Ar and X are as specified in the description, and to their physiologically tolerated salts, methods for the preparation of these compounds and their use as medicaments.These compounds are poly(ADP-ribose) polymerase (PARP) inhibitors.