Preparation of thiazoles

US7795442B2 · kind B2 · utility

Assignee

• Syngenta Crop Protection AG · CH

Inventors

• Thomas Pitterna · Chur, CH
• Henry Szczepanski · Möhlin, CH
• Peter Mainenfisch · Chur, CH
• Ottmar Franz Huter · Bad Kötzting, DE
• Thomas Rapold · Laufenburg, CH
• Marcel Senn · Basel, CH
• Thomas Gobel · Lörrach, DE
• Anthony Cornelius O'Sullivan · Basel, CH

Key dates

• Filing date: Apr 16, 2009
• Grant date: Sep 14, 2010
• Expiry date: Apr 16, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D277/74
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A process is provided for preparing compounds having the general formula Iwherein R is a range of organic groups and X is a leaving group. The process comprises reacting a compound of formula IIwith a water-removing reagent. When X is halogen or a sulfonate, the compound of formula I may be prepared by reacting a compound of the formula IIIwith a halogenating agent or a sulfonylating agent. Alternatively, when X is halogen, the compound of formula I can be prepared by reacting a compound of the formula IVwhere R2 and R2 are defined organic groups, with a compound of the formula halogen-C(—O)—O—C1-C8alkyl, halogen-C(—O)—O-aryl or halogen-C(—O)—O-benzyl.