Substituted 2-aminoalkylthiobenzimidazole compounds, pharmaceutical compositions thereof and methods for their use

US7795445B2 · kind B2 · utility

Assignee

• Sanofi-Aventis · FR

Inventors

• Elisabeth Defossa · Idstein, DE
• Karl Schoenafinger · Alzenau, DE
• Gerhard Jaehne · Frankfurt, DE
• Christian Buning · Frankfurt am Main, DE
• Georg Tschank · Frankfurt am Main, DE
• Ulrich Werner · Frankfurt am Main, DE

Key dates

• Filing date: Sep 14, 2007
• Grant date: Sep 14, 2010
• Expiry date: Sep 14, 2027

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P9/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention comprises the substituted 2-aminoalkylthiobenzimidazoles of formula Iwherein R1-R5 and R11-R16 are hereinafter defined. These compounds, their derivatives and the pharmaceutically acceptable salts thereof are useful in the reduction of elevated blood sugar levels and are therefore useful in the treatment of hyperglycemia, diabetes, atherosclerosis and other blood sugar disorders. These compounds are particularly suitable in the treatment of type-2 diabetes.