Hyperpolarized dynamic chemical shift imaging with tailored multiband excitation pulses

US7795868B2 · kind B2 · utility

Assignees

• The Board of Trustees of the Leland Stanford Junior University · US
• The Regents of the University of California · US

Inventors

• Peder Larson · Redwood City, US
• John M. Pauly · Stanford, US
• Daniel B. Vigneron · Corte Madera, US
• Albert Chen · San Francisco, US
• Adam B. Kerr · Palo Alto, US

Key dates

• Filing date: Oct 8, 2008
• Grant date: Sep 14, 2010
• Expiry date: Oct 8, 2028

Classification

• Technology area (CPC G): Physics
• CPC primary: G01R33/485
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

A method for performing magnetic resonance spectroscopy is described. The method generally includes applying a tailored multiband spectral-spatial radio frequency excitation pulse to a sample including a first species and at least a second species having a different resonant frequency than the first species. The multiband excitation pulse excites the first species according to a first amplitude and excites the second species according to a second amplitude that is substantially greater than the first amplitude. Data is acquired from the sample. The acquired data is then utilized to generate a spectroscopic output. By way of example, the spectroscopic output is a spectroscopic image. In particular embodiments, the data for the first and second species is acquired dynamically over an observation window of time.