Association of polymorphisms in the SOST gene region with bone mineral density
US7799523B2 · kind B2 · utility
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9Claims
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Key dates
| Filing date | Apr 3, 2003 |
| Grant date | Sep 21, 2010 |
| Priority date | — |
| Expiry date | May 24, 2025 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q2600/156
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Compositions and methods are provided for determining in a subject a risk for having, or presence of, altered bone mineral density such as osteoporosis or osteopenia or other conditions characterized by decreased or increased bone density. Specifically, the invention relates to determination of a sclerostin gene region nucleotide polymorphism (SRP) in DNA of the sclerostin gene region of human chromosome 17. In certain embodiments, SRPs that indicate an increased risk for altered bone mineral density occur as gender-associated polymorphisms. Isolated polynucleotides comprising representative SRPs are also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.