Salts of substituted 5-membered azacycle and use thereof in the treatment of diseases related to protein aging
US7799813B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jan 29, 2007 |
| Grant date | Sep 21, 2010 |
| Priority date | — |
| Expiry date | Jan 29, 2027 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P27/12
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to 5-membered azacycle compounds of formula (I), pharmaceutically acceptable salts thereof and hydrates thereof, wherein the groups are as defined in the specification. The present invention further relates to pharmaceutical compositions containing said compounds or pharmaceutically acceptable salts thereof or hydrates thereof, and to use of the pharmaceutical compositions in (i) improving skin elasticity or reducing skin wrinkles, (ii) treating diabetes, (iii) treating or relieving adverse sequelae of diabetes, (iv) treating or relieving kidney damage, (v) treating or relieving damage to blood vasculature, (vi) treating or relieving hypertension, (vii) treating or relieving retinopathy, (viii) treating or relieving damage to lens proteins, (ix) treating or relieving cataract, (x) treating or relieving peripheral neuropathy, or (xi) treating or relieving osteoarthritis. The present invention further relates to use of said compounds or pharmaceutically acceptable salts thereof or hydrates thereof in the preparation of oral formulations for inhibiting or reversing tooth staining, or in the preparation of fresh-keeping agents for plant proteins of crops o…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.