Synthesis and use of 2′-substituted-N6 -modified nucleosides
US7799908B2 · kind B2 · utility
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Key dates
| Filing date | Jan 15, 2004 |
| Grant date | Sep 21, 2010 |
| Priority date | — |
| Expiry date | Jan 22, 2027 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H19/16
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
An improved method of preparing a sugar modified nucleoside analog includes a protocol in which a hydroxy group of a sugar is selectively deprotected and oxidized prior to nucleophilic modification of the corresponding carbonyl group. The modified sugar is then coupled to a heterocyclic base that is modified with a dual nucleophilic reagent in a further step that provides N6-modified adenosine analogs with high stereoselectivity.
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