Radioactive arsenic-containing compounds and their uses in the treatment of tumors
US7803350B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Jul 30, 2007 |
| Grant date | Sep 28, 2010 |
| Priority date | — |
| Expiry date | Aug 19, 2028 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P35/02
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention provides a process for producing a radioactive arsenic-containing compound, comprising the steps of: (i) subjecting an arsenic-containing compound to a neutron irradiation treatment, said arsenic-containing compound being selected from a group consisting of As2O3, As2S3, As2S2, and a combination thereof, such that the arsenic element contained in the arsenic-containing compound is converted to a radioactive arsenic isotope; and (ii) recovering the resultant product from step (i).This invention also provides a pharmaceutical composition comprising a therapeutically effective amount of the radioactive arsenic-containing compound and a pharmaceutically acceptable carrier. The pharmaceutical composition can be used in the treatment of tumors/cancers such as hematological malignancies and solid tumors.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.