Methods and compositions for increasing the efficiency of therapeutic antibodies using NK cell potentiating compounds
US7803376B2 · kind B2 · utility
16Cited by
1References
24Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jul 23, 2004 |
| Grant date | Sep 28, 2010 |
| Priority date | — |
| Expiry date | Aug 28, 2027 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2500/10
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates, generally, to methods and compositions for increasing the efficiency of therapeutic antibodies. Their efficiency is enhanced through the increase of the ADCC mechanism. More particularly, the invention relates to the use of a therapeutic antibody in combination with compounds that block an inhibitory receptor or stimulate an activating receptor of an NK cell in order to enhance the efficiency of the treatment with therapeutic antibodies in human subjects.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.