Methods of use of antibodies which recognize a protease cleavage site of an LAP fragment of TGF-β
US7803553B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Sep 3, 2004 |
| Grant date | Sep 28, 2010 |
| Priority date | — |
| Expiry date | Nov 2, 2026 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/6893
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
It is an object of the present invention to provide antibodies capable of detecting an active TGF-β generation reaction that is specific to pathogenesis, tissues, or isoforms. The present invention provides antibodies against an LAP fragment (or latent TGF-β) generated as a result of generation of active form of human TGF-β1, human TGOF-β2 and human TGF-β3. The antibodies are able to specifically recognize respective cutting edges within protease cleavage sites existing in the region from the amino acid residue glycine at position 51 to the amino acid residue arginine at position 110 of human TGF-β1, and corresponding regions of human TGF-β2 and human TGF-β3.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.