Process for preparation of water-soluble azole prodrugs
US7803949B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Dec 20, 2006 |
| Grant date | Sep 28, 2010 |
| Priority date | — |
| Expiry date | Jun 5, 2027 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P43/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
An object of the present invention is to provide a process, or the like, suitable for the industrialization of effective deprotection reaction without using a toxic solvent as well as to provide a process, or the like, for preparing a water-soluble azole prodrug effectively. The present invention provides a process for preparing a salt represented by Formula (I);(wherein X represents a fluorine atom bonded at position 4 or position 5 of a phenyl group) comprising the steps of:(a) carrying out a deprotection reaction of a compound represented by Formula (II);(wherein X represents a fluorine atom bonded at position 4 or position 5 of a phenyl group)in the presence of a carbocation scavenger.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.