Method for the production of diarylcycloalkyl derivatives

US7803950B2 · kind B2 · utility

Assignee

• Sanofi-Aventis Deutschland GMBH · DE

Inventors

• Christophe Salagnad · Châtellerault, FR
• Frank Zocher · Frankfurt am Main, DE
• Andreas Burgard · Frankfurt am Main, DE
• Bernd Junker · Bad Soden, DE
• Rolf-Ludwig HOERLEIN · Frankfurt am Main, DE
• Thomas Stuedemann · Kelkheim, DE
• Claus-Jugen Maier · Weinheim, DE
• Jochen Hachtel · Frankfurt, DE
• Wolfgang Holla · Kelkheim, DE
• Christoph Tappertzhofen · Frankfurt, DE
• Berndt Kulitzscher · Esselbach, DE
• Stephane Mutti · Le Perreux-sur-Marne, FR

Key dates

• Filing date: Feb 20, 2007
• Grant date: Sep 28, 2010
• Expiry date: Jan 4, 2029

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02P20/55
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention relates generally to a process for preparing diarylcycloalkyl derivatives of the formula (I).wherein the respective R-group substituents are defined herein. These compounds of formula (I) are activators for peroxisome proliferator-activated receptors (PPAR activators) which are useful in the therapeutic treatment of a number of diseases and disorders of the central nervous system such as multiple sclerosis, Parkinson's Disease, psychiatric disorders and the like. The present invention is a novel process for preparing PPAR activators of the formula (I) which do not have the disadvantages of the processes known in the prior art. In particular, a process is provided with which the PPAR activators of formula (I) can be prepared in a suitable enantiomeric excess, i.e. high enantioselectivity, without the need for subsequent chiral chromatography.