Transgenic ungulates capable of human antibody production

US7803981B2 · kind B2 · utility

Assignee

• KYOWA HAKKO KIRIN CO., LTD. · JP

Inventors

• James Robl · Granby, US
• Philippe Collas · Oslo, NO
• Eddie Sullivan · Tea, US
• Poothappillai Kasinathan · Sioux Falls, US
• Richard Goldsby · Leverett, US
• Yoshimi Kuroiwa · Takasaki, JP
• Kazuma Tomizuka · Shibukawa, JP
• Isao Ishida · Shibuya, JP
• Barbara Osborne · Leverett, US

Key dates

• Filing date: Jun 20, 2007
• Grant date: Sep 28, 2010
• Expiry date: Mar 16, 2028

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2800/208
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The invention features novel methods for the production of large quantities of xenogenous antibodies, such as human antibodies. Preferably, this result is effected by inactivation of IgM heavy chain expression and, optionally, by inactivation of Ig light chain expression, and by the further introduction of an artificial chromosome which results in the expression of xenogenous antibodies (e.g., non-bovine antibodies), preferably human antibodies.