Nitro-imidazole hypoxia imaging agents
US7807394B2 · kind B2 · utility
3Cited by
1References
16Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Apr 4, 2008 |
| Grant date | Oct 5, 2010 |
| Priority date | — |
| Expiry date | Sep 10, 2028 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D403/12
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention relates to novel radioactively labeled bioreducible tracers of Formula I useful for detecting hypoxic tumors or ischemic tissue in vivo. In one embodiment, the tracers consist of a 2-nitroimidazole moiety, a triazole, metabolically stable linker with pharmacokinetics enhancing substituents, and a radioisotope. The preferred in vivo imaging modality is positron emission tomography.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.