Circular DNA molecule having a conditional origin of replication, process for their preparation and their use in gene therapy
US7807444B2 · kind B2 · utility
3Cited by
24References
1Claims
0Family size
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Key dates
| Filing date | Sep 15, 2006 |
| Grant date | Oct 5, 2010 |
| Priority date | — |
| Expiry date | Sep 15, 2026 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K48/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A circular DNA molecule, useful for gene therapy, comprising at least one nucleic acid sequence of interest, characterised in that the region allowing the replication thereof has an origin of replication with a functionality in a host cell that requires the presence of at least one specific protein foreign to said host cell. A method for preparing same, cells incorporating said DNA molecules and uses thereof in gene therapy are also described.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.