Microfluidic magnetophoretic device and methods for using the same

US7807454B2 · kind B2 · utility

Assignee

• The Regents of the University of California · US

Inventors

• Sang-Hyun Oh · Plymouth, US
• Amarendra Kumar Singh · Pune, IN
• Yanting Zhang · Goleta, US
• Dharmakirthi Nawarathna · Tustin, US
• Unyoung Kim · Palo Alto, US
• Patrick Sean Daugherty · Lompoc, US
• Hyongsok Soh · Lompoc, US
• Brian Scott Ferguson · Goleta, US

Key dates

• Filing date: Oct 18, 2006
• Grant date: Oct 5, 2010
• Expiry date: Jun 15, 2029

Classification

• Technology area (CPC B): Performing Operations; Transporting
• CPC primary: B03C2201/18
• WIPO field: Chemical engineering
• WIPO sector: Chemistry

Abstract

A microfluidic device may employ one or more sorting stations for separating target species from other species in a sample. The separation is driven by magnetophoresis. A sorting station generally includes separate buffer and sample streams. A magnetic field gradient applied to the sorting station deflects the flow path of magnetic particles (which selectively label the target species) from a sample stream into a buffer stream. The buffer stream leaving the sorting station is used to detect or further process purified target species labeled with the magnetic particles.