Patent · US Expired

Peptide inhibitors of toxins derived from LL-37

US7807617B2 · kind B2 · utility

0Cited by

2References

11Claims

0Family size

Assignee

ACADEMISCH ZIEKENHUIS LEIDEN (H.O.D.N. LUMC) GMBH · NL

Inventors

Johannes Jakobus Grote · Goslar, DE
Jan Wouter Drijfhout · Leiden, NL

Key dates

Filing date	Jan 27, 2004
Grant date	Oct 5, 2010
Priority date	—
Expiry date	Jul 28, 2025

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61K48/00
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The invention relates to a peptidic compound with affinity to bacterial and fungal toxins, especially to lipopolysaccharide or lipoteichoic acid. The peptidic compound includes an amino acid sequence X1KEFX2RIVX3RIKX4FLRX5LVX6, wherein X1 represents the N-terminal part: X2 is K or E; X3 is Q or E; X4 is D or R; X5 is N or E; X6 represents the C-terminal part: an amino acid of the core sequence is optionally derivatized; the N-terminal part is acetylated, and/or the C-terminal part is amidated, and/or the sequence differs from the native amino acid sequence X1KEFKRIVQRIKDFLRNLVX6.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.