Oxy substituted chalcones as antihyperglycemic and antidyslipidemic agents

US7807712B2 · kind B2 · utility

Inventors

• Ram Pratap · Lucknow, IN
• Mavurapu Satyanarayana · Lucknow, IN
• Chandeshwar Nath · Lucknow, IN
• Ram Raghubir · Lucknow, IN
• Anju Puri · Lucknow, IN
• Ramesh Chander · Lucknow, IN
• Priti Tiwari · Lucknow, IN
• Brajendra Kumar Tripathi · Lucknow, IN
• Arvind Kumar Srivastava · Lucknow, IN

Key dates

• Filing date: Dec 22, 2004
• Grant date: Oct 5, 2010
• Expiry date: Dec 22, 2024

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention provides appropriately substituted chalcones, such as, for example, represented by the structural formula as shown herein belowWherein R1, R2 and R3 are selected from the group consisting of H, OH, O-alkyl, O-phenyl and O-substituted phenyl; B represents Ar—Z—O or RO; where Z is an alkane having up to 5 carbon atoms; R is substituted propanol amino, wherein substituted amino groups are selected from the group consisting of t-butyl, n-butyl, i-butyl, i-propyl, 4-phenyl piperazine-1-yl, 4-(2-methoxyphenyl)-piperazin-1-yl and 3,4-dimethoxy phenethyl; and Ar is thiazolidine-dione methylene phenoxy. The compounds prepared have been demonstrated to exhibit significant antidiabetic effect in various animal models indicating potential for further exploitation.