Methods and compositions for improving recombinant protein production
US7807804B2 · kind B2 · utility
7Cited by
3References
38Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Oct 5, 2005 |
| Grant date | Oct 5, 2010 |
| Priority date | — |
| Expiry date | Aug 24, 2026 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2810/859
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Nucleic acid molecules modified to enhance recombinant protein, e.g., antibody, expression and/or reduce or eliminate mis-spliced and/or intron read-through (IRT) by-products are disclosed. The invention also provides methods for producing proteins devoid of mis-spliced and/or intron read-through by-products by the use of such vectors in host cells under cell culture conditions suitable for recombinant protein expression.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.