Transgenic bovine having reduced prion protein activity and uses thereof
US7807863B2 · kind B2 · utility
6Cited by
104References
14Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Sep 5, 2008 |
| Grant date | Oct 5, 2010 |
| Priority date | — |
| Expiry date | Sep 5, 2028 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2800/30
- WIPO fieldOther special machines
- WIPO sectorMechanical engineering
Abstract
The invention provides cloned transgenic ungulates (e.g., bovines) in which prion protein activity is reduced by one or more genetically engineered mutations. Desirably, these transgenic bovines are also genetically modified to express xenogenous (e.g., human) antibodies. Because of their resistance to prion-related diseases such as bovine spongiform encephalopy (also known as mad cow disease), these bovines are a safer source of human antibodies for pharmaceutical uses and a safer source of agricultural products.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.