Transgenic animal as a model for fibrotic diseases
US7807864B2 · kind B2 · utility
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9Claims
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Key dates
| Filing date | Feb 21, 2006 |
| Grant date | Oct 5, 2010 |
| Priority date | — |
| Expiry date | Feb 21, 2026 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2830/85
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Disclosed is a transgenic non-human animal with broad or cell type-specific ectopic expression of fra-2 that manifests itself in a fibrotic disease, methods for obtaining such animal and their use. Fra-2 transgenic animals, in particular mice, are useful as model systems for human fibrotic disease, e.g. lung scleroderma and pulmonary fibrosis. Cells obtained from the animal are useful for the analysis of fibrotic disease and for testing compounds useful in the therapy of fibrotic disease.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.