Anti-addl antibodies and uses thereof
US7811563B2 · kind B2 · utility
3Cited by
7References
14Claims
0Family size
Assignees
Inventors
Key dates
| Filing date | Oct 21, 2005 |
| Grant date | Oct 12, 2010 |
| Priority date | — |
| Expiry date | Mar 19, 2027 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/2821
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention relates to antibodies that differentially recognize multi-dimensional conformations of Aβ-derived diffusible ligands, also known as ADDLs. The antibodies of the invention can distinguish between Alzheimer's Disease and control human brain extracts and are useful in methods of detecting ADDLs and diagnosing Alzheimer's Disease. The present antibodies also block binding of ADDLs to neurons, assembly of ADDLs, and tauphosphorylation and are there useful in methods for the preventing and treating diseases associated with soluble oligomers of amyloid β 1-42.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.