Patent · US Active

Imidazole derivatives having a positive allosteric GABAB receptor modulator effect and methods of use

US7812026B2 · kind B2 · utility

1Cited by

7References

14Claims

0Family size

Assignee

ASTRAZENECA AB · SE

Inventors

Udo Bauer · Achern, DE
Wayne Brailsford · Timrå, SE
Linda Gustafsson · Timrå, SE
Tor Svensson · Timrå, SE

Key dates

Filing date	Dec 21, 2006
Grant date	Oct 12, 2010
Priority date	—
Expiry date	Dec 21, 2026

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D471/04
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

The present invention relates to novel imidazole derivatives having a positive allosteric GABAB receptor (GBR) modulator effect, methods for the preparation of said compounds and to their use, optionally in combination with a GABAB agonist, for the inhibition of transient lower esophageal sphincter relaxations, for the treatment of gastroesophageal reflux disease, as well as for the treatment of functional gastrointestinal disorders and irritable bowel syndrome (IBS). The compounds are represented by the general formula (I) wherein R1, R2, R3 and R4 are as defined in the description. For example, R1 may be phenyl, R2 may be dimethylamino pyrrolidin-1-yl, R3 may be alkoxy and R4 may be alkyl, ai arylalkyl, aryloxyalkyl, aryloxy or heterocyclylalkyl.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.