Pharmaceutical compositions of β-lapachone and β-lapachone analogs with improved tumor targeting potential
US7812051B2 · kind B2 · utility
5Cited by
20References
2Claims
0Family size
Assignee
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Key dates
| Filing date | Aug 11, 2005 |
| Grant date | Oct 12, 2010 |
| Priority date | — |
| Expiry date | Jun 27, 2027 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB82Y5/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to polymer-modified quinone-containing and carbonyl-containing therapeutic agents, including polymer-modified β-lapachone compounds, and methods of treating cancer by administering the polymer-modified therapeutic agents to a subject. Polymer-modification of therapeutic agents, such as β-lapachone compounds, provides effective transport of polymer-modified therapeutic agents to tumor cells or tumor tissues by exploiting the EPR effect in tumor tissues.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.