Hybrid hepatocyte growth factor gene having high expression efficiency of two heterotypes of hepatocyte growth factor
US7812146B2 · kind B2 · utility
6Cited by
8References
44Claims
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Key dates
| Filing date | Sep 20, 2004 |
| Grant date | Oct 12, 2010 |
| Priority date | — |
| Expiry date | Feb 24, 2029 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P9/10
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to a hybrid Hepatocyte Growth Factor (HGF) gene which is prepared by inserting an inherent or foreign intron between exons 4 and 5 in HGF cDNA, which has a base sequence of SEQ ID NO: 2. The gene has high expression efficiency and simultaneously expresses two heterotypes of HGF and dHGF (deleted variant HGF). Further the gene may be used for treating or preventing ischemic or liver diseases.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.