Method of synthesis of 4-amino-thalidomide enantiomers

US7812169B2 · kind B2 · utility

Assignee

• Children's Medical Center Corporation · US

Inventors

• Anthony Treston · Rockville, US
• Jamshed H. Shah · Columbia, US
• Robert D'Amato · Cambridge, US
• Kimberly A. Hunsucker · Germantown, US
• John Rougas · Irwin, US
• Barry P. Conner · Laurel, US
• Victor Pribdula · Silver Spring, US
• Glenn Swartz · Jessup, US

Key dates

• Filing date: Nov 30, 2001
• Grant date: Oct 12, 2010
• Expiry date: May 3, 2027

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides new and useful analogs of 4-amino-thalidomide. These analogs include S(−)-4-amino-thalidomide and R(+)-4-amino-thalidomide. The invention also provides processes for making these analogs. Further, the invention provides methods for inhibiting angiogenesis and treating angiogenesis-associated diseases, including cancer and macular degeneration, by administering these compounds.