Fluorescence tomography using line-by-line forward model
US7812945B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jun 15, 2007 |
| Grant date | Oct 12, 2010 |
| Priority date | — |
| Expiry date | Nov 10, 2028 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N21/4795
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A fluorescence optical tomography system and method uses a photon migration model calculator for which absorption and reduced scattering coefficient values are determined for each source/detector pair. The coefficient values may be determined by measurement, in which a time resolved detector detects the excitation wavelength and generates temporal point spread functions from which the coefficient values are found. Alternatively, the coefficient values may be determined by calculating them from a dataset containing a spatial distribution of absorption and reduced scattering coefficients in a volume of interest. The fluorescence detection may be continuous wave, time resolved, or a combination of the two. An estimator uses a detected fluorescence signal and an estimated fluorescence signal to estimate the image values.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.