Creatinine sensor calibration

US7815788B2 · kind B2 · utility

Assignee

• Roche Diagnostics Operations, Inc. · US

Inventors

• Bernhard Schaffar · Graz, AT
• Herbert Kroneis · Graz, AT
• Taghi Noormofidi · Graz, AT
• Gernot Florian · Graz, AT
• Wolf-Dietrich Steinbock · Graz, AT

Key dates

• Filing date: Mar 28, 2008
• Grant date: Oct 19, 2010
• Expiry date: Mar 28, 2028

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Q1/34
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

In a method for calibrating a biosensor for the amperometric determination of creatinine in biological liquids, consisting of one electrode system each for measuring the concentrations of creatinine and creatine, with at least two calibration solutions being used, the electrode system for measuring the creatinine concentration is calibrated with a creatinine solution which, prior to the calibration measurement, was mixed in the form of an acidic solution with an alkaline buffer solution, and the electrode system for measuring the creatine concentration is calibrated with a solution in which creatinine and creatine are at a thermodynamic equilibrium.