Polypeptides and immunogenic conjugates capable of inducing antibodies against pathogens, and uses thereof

US7815918B2 · kind B2 · utility

Assignee

• University of Rochester · US

Inventors

• Francis Gigliotti · Scotia, US
• Terry Wright · Rochester, US
• Constantine G. Haidaris · San Diego, US
• Patricia J. Simpsonhaidaris · Rochester, US
• Jesse Wells · Rochester, US

Key dates

• Filing date: Dec 31, 2004
• Grant date: Oct 19, 2010
• Expiry date: Mar 14, 2027

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S530/823
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A number of immunologically active agents are described, including an isolated protein or polypeptide that includes the amino acid sequence of SEQ ID NO: 1, immunogenic conjugates containing either the protein or polypeptide, a full-length Pneumocystis kexin, or a full length Streptococcus pneumoniae pneumococcal surface protein A (PspA), antibodies recognizing the protein or polypeptide or the immunogenic conjugates (particularly the epitope of SEQ ID NO: 1), and nucleic acid molecules that encode the protein or polypeptide, as well as DNA constructs, expression vectors, and host cells that contain the nucleic acid molecules. Disclosed uses of the antibodies, immunogenic conjugates, and DNA constructs include inducing passive or active immunity to treat or prevent pathogen infections, particularly by a Pneumocystis organism, in a patient.