Self emulsifying drug delivery system
US7815933B2 · kind B2 · utility
Assignee
Inventor
Key dates
| Filing date | Sep 5, 2002 |
| Grant date | Oct 19, 2010 |
| Priority date | — |
| Expiry date | Dec 4, 2024 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P29/02
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention claims and discloses a pharmaceutical composition suitable for oral administration, in form of an emulsion pre-concentrate, comprising (i) one or more NO-releasing NSAID(s); (ii) one or more surfactants, of which at least one is phospholipid; said composition forming an in-situ oil-in-water emulsion upon contact with gastrointestinal fluids. The composition may optionally also comprise an additional oil or semi-solid fat. Further, one or more short-chain alcohols can optionally be included in the composition. Also within the scope of the invention is a combination with a proton pump inhibitor. The pharmaceutical composition is useful in the treatment of pain and inflammation. Further within the scope of the invention is kit comprising a pharmaceutical composition according to the invention in a unit dosage form, in combination with a proton pump inhibitor, and said proton pump inhibitor is enteric coated.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.