Patent · US Active

Tripeptide prodrug compounds

US7816317B2 · kind B2 · utility

13Cited by

5References

26Claims

0Family size

Assignee

MEDAREX INC. · US

Inventors

Christopher R. Bebbington · San Mateo, US
Vincent Dubois · Ittre, BE
Sanjeev Gangwar · Foster City, US
Thomas J. Lobl · Valencia, US
Matthew H. Nieder · Seattle, US
Lesley Pickford · Menlo Park, US
Andre Trouet · Winksele, BE
Geoffrey T. Yarranton · Burlingame, US

Key dates

Filing date	Mar 27, 2007
Grant date	Oct 19, 2010
Priority date	—
Expiry date	Nov 3, 2028

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61K38/00
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The prodrug of the invention is a modified form of a therapeutic agent and comprises a therapeutic agent, an oligopeptide of three amino acids, a stabilizing group and, optionally, a linker group. The prodrug is cleavable by a trouase enzyme such as Thimet oligopeptidase. Also disclosed are methods of making and using the prodrug compounds.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.