Substituted pyrrolidinones as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
US7816349B2 · kind B2 · utility
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16Claims
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Key dates
| Filing date | Apr 23, 2007 |
| Grant date | Oct 19, 2010 |
| Priority date | — |
| Expiry date | Oct 13, 2027 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D401/10
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention discloses novel compounds of Formula I: (I) possessing 11β-HSD type 1 antagonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula I, as well as methods of using the compounds and compositions to treat diabetes, hyperglycemia, obesity, hypertension, hyperlipidemia, metabolic syndrome, cognitive disorders, and other conditions associated with 11β-HSD type 1 activity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.