Patent · US Active

Use of acacetin and related compounds as potassium channel inhibitors

US7816400B2 · kind B2 · utility

1Cited by

0References

10Claims

0Family size

Assignees

University of Hong Kong · CN
SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES · CN

Inventors

Gui-Rong Li · Hong Kong, CN
Chu-Pak Lau · Hong Kong, CN
Guo-Wei Qin · Shanghai, CN
Hong Wang · Shanghai, CN

Key dates

Filing date	Feb 29, 2008
Grant date	Oct 19, 2010
Priority date	—
Expiry date	May 9, 2028

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61P9/06
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

This invention provides a method for treating or preventing human atrial arrhythmia (fibrillation) using the leading flavone compound acacetin, and its derivatives and analogues that inhibit the ultra-rapidly-activating delayed rectifier potassium current (IKur or IKsus), transient outward potassium (Ito), and acetylcholine-activated potassium current (IK.ACh).

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.