Conjugates of hydroxyalkyl starch and an active agent

US7816516B2 · kind B2 · utility

Assignee

• Fresenius Kabi Deutschland GmbH · DE

Inventors

• Klaus Sommermeyer · Rosbach, DE
• Wolfram Eichner · Rockenberg, DE
• Sven Frie · Bramois, CH
• Cornelius Jungheinrich · Bad Homburg vor der Höhe, DE
• Roland Scharpf · Ranstadt, DE
• Katharina Lutterbeck · Friedberg, DE
• Jurgen Hemberger · Aschaffenburg, DE
• Michele Orlando · The Hague, NL

Key dates

• Filing date: Mar 15, 2002
• Grant date: Oct 19, 2010
• Expiry date: Mar 20, 2024

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to compounds, comprising a conjugate of hydroxyalkyl starch (HAS) and an active agent, whereby the hydroxyalkyl starch is either directly covalently bonded to the active agent, or by means of a linker. The invention further relates to methods for the production of a covalent HAS-active agent conjugate, whereby HAS and an active agent are reacted in a reaction medium, characterised in that the reaction medium is water or a mixture of water and an organic solvent, comprising at least 10 wt. % water.