Methods and apparatus for treating infarcted regions of tissue following acute myocardial infarction
US7819856B2 · kind B2 · utility
Assignee
Inventor
Key dates
| Filing date | Oct 5, 2004 |
| Grant date | Oct 26, 2010 |
| Priority date | — |
| Expiry date | Jan 28, 2027 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61M2025/0002
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
Apparatus and methods are provided for treating an infarcted region of myocardium following acute myocardial infarction by reducing the rate of blood flow through infarcted region, and then injecting a solution containing stem cells, endothelial progenitor cells or mediators of stem cell mobilization, migration and attachment into the effected region so that the stem cells become embedded therein and promote tissue regeneration. In a first embodiment, delivery of the stem cells, endothelial progenitor cells or mediators of stem cell mobilization, migration and attachment is accomplished using a catheter that relies upon antegrade flow through the coronary artery and a flow control catheter placed in the coronary sinus. In an alternative embodiment, the delivery catheter delivers the stem cells in a retrograde manner through the coronary sinus, and the delivery catheter further comprises an occlusion balloon for controlling outflow through the coronary sinus ostium.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.