Anti-hepcidin antibodies and uses thereof
US7820163B2 · kind B2 · utility
4Cited by
1References
9Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Oct 29, 2008 |
| Grant date | Oct 26, 2010 |
| Priority date | — |
| Expiry date | Dec 22, 2028 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2317/92
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Monoclonal antibodies are provided that selectively bind human hepcidin-25 and are characterized as having high affinity for human hepcidin-25 and strong human mature hepcidin neutralizing properties. The antibodies of the invention are useful therapeutically for increasing serum iron levels, reticulocyte count, red blood cell count, hemoglobin, and/or hematocrit in a human and for the treatment and diagnosis of mature hepcidin-promoted disorders such as anemia, in a human subject.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.