Listeria-based and LLO-based vaccines
US7820180B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Sep 13, 2005 |
| Grant date | Oct 26, 2010 |
| Priority date | — |
| Expiry date | Sep 13, 2025 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2039/6068
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention provides methods of treating and vaccinating against an antigen-expressing tumor and inducing an immune response against a sub-dominant epitope of antigen, comprising a fusion of an LLO fragment to the antigen or a recombinant Listeria strain expressing the antigen. The present invention also provides recombinant peptides comprising a listeriolysin (LLO) protein fragment fused to a Her-2 protein or fragment thereof, recombinant Listeria strains expressing a Her-2 protein, vaccines and immunogenic compositions comprising same, and methods of inducing an anti-Her-2 immune response and treating and vaccinating against a Her-2-expressing tumor, comprising same.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.